Influence of Some Physicochemical Exposure Factors on the Metronidazole Content of a Pharmaceutical Product: Flagyl® 250 mg Tablet

The present work aims to study the influence of some physicochemical parameters (light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen peroxide) on content Metronidazole (MTZ) contained in reference substance (SR) and a pharmaceutical specialty Flagyl® 250 mg tablet (FLG). method developed was linear accurate accordance with USP 38 MTZ contents were obtained by UV-visible spectrophotometry at 278 nm. These ranged from 225 275 thus consistent concentration proprietary medicines (250 mg). SR FLG showed that are unstable presence Ethanol 96˚, KOH 0.1N salts but also when temperature is higher than 25˚C. However, they remain stable light H2O2 undergo degradation an acidic environment.